Taken together, these findings suggest that APR-246 could induce tumor cell death through both reactivation of mutant p53 and inhibition of cellular thiol-dependent redox system proteins (GPX4, TXNDR1, GRX1), providing novel combinatorial strategies for AML therapy
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a maintenance dose of 50 mg/kg (to a maximum of 3 g/dose) administered every 8 hours may be used
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Always consult a qualified healthcare provider before making decisions about testing, treatment, or lifestyle changes that could affect your health
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